Views: 0 Author: Site Editor Publish Time: 2025-04-21 Origin: Site
In the world of modern aesthetics, injectable dermal fillers have transformed facial rejuvenation, enabling patients to restore volume, contour facial features, and smooth fine lines with minimal downtime. However, not all fillers are created equal. Beneath their shared appearance lies a critical difference: the internal structure of the filler, which plays a vital role in determining its performance, longevity, and visual effects.
At the core of this distinction is the comparison between biphasic fillers and monophasic fillers. The way hyaluronic acid (HA) particles are suspended and organized at the microscopic level dictates texture, spreadability, lifting capacity, and hydration ability.
The main structural distinction between biphasic and monophasic fillers lies in how the HA gel matrix is created:
Biphasic fillers consist of crosslinked hyaluronic acid (HA) particles suspended in a gel made from non-crosslinked or lightly crosslinked HA. This two-phase structure creates a product that offers both structural rigidity and injectability.
The HA particles provide robust volumizing and lifting power, making them ideal for areas requiring shape enhancement and deep tissue support.
The gel carrier allows for smoother injection and easier placement within tissue planes.
Cheek augmentation, jawline contouring, and chin projection
Deep folds such as nasolabial folds
Areas where long-lasting structure is needed
Clinical Note: Due to the particulate phase, biphasic fillers are more moldable and offer strong projection but may feel firmer to the touch and require skillful injection to prevent visible lumping.
Monophasic fillers are made from a homogeneous gel of fully crosslinked HA, meaning the entire product maintains a consistent texture with no separate particle phase.
Provides a silky-smooth texture, ensuring even distribution and seamless integration with surrounding tissue.
Minimizes risk of lump formation, even in areas with thin skin.
Fine lines, perioral wrinkles, and superficial injections
Tear troughs and lip enhancement, where subtlety and natural flexibility are prioritized
Enhancing skin hydration and elasticity
Pro Tip: Monophasic fillers can be complemented with Mesotherapy—using non-crosslinked HA—to maximize hydration and tissue vitality, especially in dynamic facial zones.
These structural differences result in distinct handling properties, viscosity, and tissue interaction, impacting both practitioner technique and patient results.
Biphasic fillers contain discrete HA particles that give them a granular texture and provide a strong scaffolding effect. These are often more resistant to deformation, making them suitable for areas requiring volume projection and lifting, such as the cheeks or chin.
Monophasic fillers, by contrast, feature a smooth and consistent matrix. This design allows for better flow and blending within the dermis, offering a natural transition and silky finish, which is perfect for areas like tear troughs, lips, or fine nasolabial folds.
Parameter | Biphasic Filler | Monophasic Filler |
Cohesiveness | Moderate | High |
Elasticity | High | Moderate |
Integration | Moderate | Excellent |
Projection Ability | Strong | Subtle |
Spreadability | Limited | Broad |
Ideal Use | Deep-volume areas | Superficial and dynamic areas |
Monophasic fillers excel in delivering uniform texture without palpable lumps. Their seamless integration helps in reducing the appearance of fine lines, particularly in periorbital, perioral, and forehead areas, where delicacy and evenness are paramount.
Biphasic fillers are favored when structure and lift are required. For instance, in chin augmentation, cheekbone definition, or nasal reshaping, the firm HA particles in biphasic fillers resist gravity and create sharper contours.
Due to their continuous gel phase and higher HA concentration in free form, monophasic fillers often possess strong water-retaining properties, resulting in improved skin suppleness and glow. They are particularly synergistic with Mesotherapy, offering both volumization and hydration.
With higher elastic modulus (G'), biphasic fillers are ideal for firming sagging skin and reinforcing dermal structures, providing longer-lasting lift and supportive volume where needed.
Each part of the face has unique anatomical features and movement patterns, which should guide filler selection.
Goal: Soft, natural enhancement with hydration and flexibility.
Recommended Filler: Monophasic fillers—thanks to their smooth, homogenous texture, they integrate seamlessly into delicate lip tissue, avoiding lumpiness and allowing dynamic movement.
Expert Tip: For added softness and improved hydration, combine with Mesotherapy using non-crosslinked HA to nourish and plump from within.
Goal: Restore volume and reduce deepening of smile lines while preserving facial expression.
Monophasic fillers for superficial lines, offering gentle correction and skin flexibility.
Biphasic fillers for deeper folds, where structural support and volume retention are necessary.
Clinical Insight: A hybrid approach allows tailored correction based on fold severity and patient age.
Goal: Restore volume loss, enhance cheek projection, and provide midface lifting.
Recommended Filler: Biphasic fillers—their particulate structure offers firm support and excellent lift capacity, making them ideal for volumizing the cheeks.
Bonus Benefit: Long-lasting results with minimal migration due to the stable, cohesive gel matrix.
Goal: Correct hollowing and discoloration without causing puffiness or visible irregularities.
Recommended Filler: Monophasic fillers with low viscosity and high spreadability.
Why It Works: These fillers offer smooth integration into thin, sensitive under-eye tissue and reduce the risk of the Tyndall effect or lump formation.
Goal: Achieve well-defined contours, improved symmetry, and structural enhancement.
Recommended Filler: High-density biphasic fillers—these provide strong projection and molding capabilities for precision sculpting.
Durability Advantage: Their firmer structure allows for longevity and resistance to deformation in high-pressure areas like the nose and chin.
While traditional dermal fillers offer volume and shape, Mesotherapy introduces a subtle, skin-enhancing component to treatment plans. This non-crosslinked HA technique delivers hydration, brightening, and regenerative nutrients via microinjections—especially beneficial for enhancing overall skin quality in areas adjacent to filler-treated zones. For example:
Before filler: Mesotherapy preps the skin, improving elasticity.
After filler: It prolongs results and maintains a youthful glow.
Standalone: Suitable for younger patients or those focused on skin vitality rather than contouring.
An experienced injector takes into account not only aesthetic goals but also filler rheology, tissue characteristics, and patient-specific anatomy. Key questions include:
Does the area require lift or blend?
Is the target static (e.g., nose) or dynamic (e.g., lips)?
Are we treating surface wrinkles or deep volume loss?
Monophasic for superficial layers and movement-prone areas.
Biphasic for foundational support in static or voluminous zones.
Combine Mesotherapy for enhanced hydration and skin quality improvement.
The design of a dermal filler—whether biphasic or monophasic—plays a decisive role in determining aesthetic outcome, longevity, and tissue compatibility. Understanding these differences allows physicians to customize treatment plans for optimal results tailored to each patient's facial anatomy and goals.
With the increasing emphasis on natural-looking enhancements, selecting the right filler structure has become just as important as choosing the right technique or injection site.
For medical professionals seeking high-quality, scientifically backed fillers, we highly recommend Shandong Bouliga Biotechnology Co., LTD. As a prominent name in the field of hyaluronic acid research and manufacturing, Bouliga offers:
A full line of biphasic and monophasic fillers
Non-crosslinked HA gels for joint injection and Mesotherapy
OEM & customized formulation services
Products compliant with ISO, CE, and GMP standards
Whether you're performing a nose augmentation, lip contouring, or Mesotherapy hydration treatment, Bouliga provides reliable, safe, and high-performance solutions to help achieve your desired results.
